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MediLink Therapeutics Announces B7-H3 ADC YL201 Met Primary Endpoint in Phase 3 Nasopharyngeal Carcinoma Study

SUZHOU, China – May 29, 2026 – MediLink Therapeutics (Suzhou) Co., Ltd. today announced that tambotatug pelitecan (tam-peli, R&D code: YL201), its investigational B7-H3 targeted antibody-drug conjugate (ADC), has achieved positive results in the pre-specified interim analysis of the Phase 3 registrational clinical trial (TAISHAN-301) for recurrent or metastatic nasopharyngeal carcinoma (NPC). The Independent Data Monitoring Committee (IDMC) confirmed that the trial met the endpoint of confirmed objective response rate (cORR) as assessed by Blinded Independent Central Review (BICR), demonstrating a statistically significant improvement compared to chemotherapy. The second co-primary endpoint of overall survival (OS) is not yet mature. This marks the first positive Phase 3 result for any B7-H3 targeted ADC worldwide.

2026-05-30

Shining at ASCO 2026 | MediLink Therapeutics Presents Multiple Clinical Studies, Showcasing ADC Innovation

The 2026 American Society of Clinical Oncology (ASCO) Annual Meeting will take place May 29 – June 2 in Chicago, IL. As the world’s largest, most influential, and authoritative oncology conference, ASCO drives global progress in cancer research, clinical development, and patient care.

2026-05-20

MediLink Therapeutics Presents Two Innovative ADC Programs at AACR 2026

MediLink Therapeutics, a clinical-stage biotechnology company focused on next-generation antibody-drug conjugates (ADCs), is pleased to share two cutting-edge research posters at the AACR 2026 Annual Meeting (April 17–22, San Diego, USA).

2026-04-23

MediLink Therapeutics Announces Strategic Collaboration and Worldwide License Agreement with BioNTech

MediLink Therapeutics (“MediLink”), announced today that it has entered into a strategic research collaboration and worldwide license agreement with BioNTech SE (Nasdaq: BNTX, "BioNTech"), a next generation immunotherapy company pioneering novel therapies for cancer and other serious diseases, on the development of a next-generation antibody-drug conjugate candidate (“ADC”), against Human Epidermal Growth Factor Receptor 3 (HER3).

2023-10-12Learn more

MediLink Therapeutics: Focuses on ADC research and development to promote new prospects for cancer treatment

GUANGZHOU, China, Sept. 23, 2023 /PRNewswire/ -- On September 23, 2023, oncologists and experts from more than 60 clinical research centers across the country gathered in Guangzhou to participate in the YL201 Phase I/II Investigators Meeting hosted by Suzhou MediLink Therapeutics Co., Ltd. The chair of this meeting was Professor Li Zhang, from the Cancer Center of Sun Yat-sen University, who gathered the wisdom and experience of experts, to discuss the development strategy of the clinical trial protocol in depth, and lay a solid foundation for the efficient drug development of YL201.

2023-09-23Learn more

MediLink Therapeutics is studying YL202 in advanced lung and breast cancer patients.

Working as a Clinical Research Coordinator I frequently find myself in the situation of balancing trial demands, patients’ comfort and executing protocol instructions correctly. I make the best of my resources and ask for assistance when needed. Hence, it should go without saying, having a reliable team is of paramount importance! Here is where, in my most recent experience, MediLink Therapeutics excels.

2023-08-25Learn more

PHARMCUBE interview - Dr. Xue, founder of Medilink Therapeutics

2023-03-02Learn more

MediLink Dosed 1st Patient in Phase I Study with ADC YL202

MediLink Therapeutics today announced that the first patient has been successfully dosed with its Antibody Drug Conjugate (ADC) product YL202 in the United States and the first dose was well tolerated without any adverse events (AEs) observed. This is a multi-center nonrandomized, open-label, first-in-human phase I study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of YL202 in patients with locally advanced or metastatic epidermal growth factor receptor (EGFR)-mutated Non-small cell lung cancer (NSCLC) or hormone receptor (HR)-positive and HER2-negative breast cancer (BC). “The initiation of this study represents a significant milestone for MediLink Therapeutics, as it marks the second program of our ADC platform to enter the clinic in less than one year”, stated Tony Xue, PhD, Chairman, Founder & CEO.

2023-02-14Learn more

Jiangsu Public TV visit MediLink

2022-10-28Learn more

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